Unlocking the potential of regenerative cells for patients suffering
from serious chronic illnesses by developing and delivering
innovative and effective human therapeutics.
The human body has a remarkable innate ability to heal.
Our technology is designed to unleash that natural healing power.
Paracrine is developing a disease modifying First-in-Class cell therapy
addressing underlying pathology - leading to rapid and durable healing
Executing The ASCEND Clinical Trial
An FDA Approved Phase III Trial in Patients with Diabetic Foot Ulcers
Data from four prior independent feasibility studies demonstrated a wound closure rate of 88%,
nearly four times the standard of care and twice that reported with advanced wound care products.
Wound closure was accomplished with a single treatment.
Healing was rapid with median time to wound closure in less than half the time of current products.
Results were durable with no recurrences reported in up to 18 months of follow-up.
Unlocking the potential of regenerative cells for patients suffering from serious chronic illnesses by developing and delivering innovative and effective human therapeutics.
The human body has a remarkable innate ability to heal.
Our technology is designed to unleash that natural healing power...
Unlocking the potential of regenerative cells for patients suffering from serious chronic illnesses by developing and delivering innovative and effective human therapeutics.
The human body has a remarkable innate ability to heal.
Our technology is designed
to unleash that natural
healing power...
HIGHLY EFFECTIVE BIOLOGIC IN LATE-STAGE CLINICAL TRIALS POISED TO DISRUPT THE $21 BILLION WOUND CARE MARKET
Executing the ASCEND Clinical Trial
An FDA Approved Phase III Trial
In Patients with Diabetic Foot Ulcers
A disease modifying first-in-class cell therapy addressing the underlying pathology - leading to rapid and durable healing
Data from prior independent feasibility studies demonstrated a wound closure rate of 88%,
nearly four times the standard of care.
Healing was accomplished with a single treatment.
Results were durable with no recurrences reported
in up to 18 months follow-up.
Executing The ASCEND Trial
FDA Approved Phase III Trial
In Diabetic Foot Ulcers (DFUs)
Paracrine's Personalized Therapy
is a disease modifying
First-in-Class Cell Therapy
that addresses the underlying pathology - leading to rapid
and durable healing
Data from prior independent feasibility studies demonstrated a wound closure rate of 88%, nearly four times the standard of care -
from a single treatment.
Healing was rapid and durable, with no recurrences reported to 18 months follow-up.
Ripe for Innovation & Disruption
What is Paracrine Signaling?
Paracrine Signaling is local communication through cell-to-cell “cross-talk”. Relatedly, endocrine signaling is long-distance communication.
Paracrine’s cells (ADRCs), secrete dozens, perhaps even hundreds, of signaling molecules in response to local environmental cues. These factors, known collectively as adipokines, regulate numerous biologic functions including the immune system, inflammation, vascular function, wound healing and tissue repair.
Disease Modifying: Adipokines address the major underlying pathology common in complex conditions: ischemia, inflammation, and tissue damage. Paracrine Cell Therapy is pleiotropic – utilizing multiple mechanisms of action necessary to achieve successful, durable outcomes.
What is Paracrine Signaling?
Paracrine Signaling is local communication through cell-to-cell “cross-talk”. Relatedly, endocrine signaling is long-distance communication (through the blood stream).
Paracrine’s cells (ADRCs), secrete dozens, perhaps even hundreds, of signaling molecules in response to local environmental cues. These factors, known collectively as adipokines, regulate numerous biologic functions including the immune system, inflammation, vascular function, wound healing and tissue repair.
Disease Modifying: Adipokines address the major underlying pathology common in complex conditions: ischemia, inflammation, and tissue damage. Paracrine Cell Therapy is pleiotropic – utilizing multiple mechanisms of action necessary to achieve successful, durable outcomes.
What is Paracrine Signaling?
Paracrine Signaling is local communication through cell-to-cell “cross-talk”. Relatedly, endocrine signaling is long-distance communication (through the blood stream).
Paracrine’s cells (ADRCs), secrete dozens, perhaps even hundreds, of signaling molecules in response to local environmental cues. These factors, known collectively as adipokines, regulate numerous biologic functions including the immune system, inflammation, vascular function, wound healing and tissue repair.
Disease Modifying: Adipokines address the major underlying pathology common in complex conditions: ischemia, inflammation, and tissue damage. Paracrine Cell Therapy is pleiotropic – utilizing multiple mechanisms of action necessary to achieve successful, durable outcomes.
Our team brings together highly experienced industry veterans with a proven track record in all aspects of innovating novel biologic products.
Our combined expertise in cell based therapy is key for delivering safe and effective biologic therapy to the clinic and market to improve the lives of people who are living with medically unaddressed, debilitating chronic diseases and conditions.
Our team brings together highly experienced industry veterans with a proven track record in all aspects of innovating novel biologic products.
Our combined expertise in cell based therapy is key for delivering safe and effective biologic therapy to the clinic and market to improve the lives of people who are living with medically unaddressed, debilitating chronic diseases and conditions.
May 12, 2022
April 4, 2022
February 2, 2022
January 25, 2022
January 4, 2022
November 17, 2021
May 12, 2022
April 4, 2022
February 2, 2022
January 25, 2022
January 4, 2022
November 17, 2021
Our team brings together highly experienced industry veterans with a proven track record in all aspects of innovating novel biologic products.
Our combined expertise in cell based therapy is key for delivering safe and effective biologic therapy to the clinic and market to improve the lives of people who are living with medically unaddressed, debilitating chronic diseases and conditions.
May 12, 2022
April 4, 2022
February 2, 2022
January 25, 2022
January 4, 2022
November 17, 2021